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  • Title: Biological activity of the three mono-beta-D-glucopyranosides of 1,25-dihydroxycholecalciferol.
    Author: Rambeck WA, Weiser H, Meier W, Labler L, Zucker H.
    Journal: Int J Vitam Nutr Res; 1985; 55(3):263-7. PubMed ID: 3841093.
    Abstract:
    The biological activity of the three mono-beta-D-glucopyranosides (mono-glucosides) of 1,25-dihydroxycholecalciferol [1,25(OH)2D3] synthesized chemically has been studied in chicks and Japanese quails. While the 1- and the 3-glucoside showed no or only little effect on serum calcium, bone weight, calcium binding protein (CaBP) or calcium deposition in the egg shell, the 25-glucoside was found to be more than half as active as the aglycone 1,25(OH)2D3. The bioactivity of this glucoside parallels a higher binding constant to the intestinal 1,25(OH)2D3 receptor compared to those of the two other glucosides.
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