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  • Title: [Beta-HCG-producing choriocarcinoma of the pineal area as a cause of precocious puberty].
    Author: Blümel P, Grümayer ER, Machacek E, Stögmann W.
    Journal: Helv Paediatr Acta; 1985; 40(6):473-9. PubMed ID: 3841665.
    Abstract:
    We report the case of an eight-year-old boy with precocious puberty due to a beta-HCG producing choriocarcinoma of the pineal region. beta-HCG-levels were elevated initially (9659 mU/ml) and did not normalize completely after surgical removal of the brain tumor. A relapse of the tumor in the hypothalamic region led to a new increase of beta-HCG-level up to 41258 mU/ml. Histopathology of a subsequently removed metastasis in the right lung showed immunohistological evidence of beta-HCG production. Introduction of chemotherapy was followed by a normalization of the beta-HCG-level and of the previously elevated hormone values.
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