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Title: Platinum(II) complexes generate frame-shift mutations in test strains of Salmonella typhimurium. Author: Andersen KS. Journal: Mutat Res; 1979 Jul; 67(3):209-14. PubMed ID: 384231. Abstract: cis-Diamminodichloroplatinum(II) (cis-PDD) and diaquoethylenediamineplatinum(II) induce histidine revertants in Salmonella typhimurium strains TA98 (frame-shift mutation) and TA100 (base-pair substitution mutation). A linear dose--response relationship is found with cis-PDD acting on TA98 and TA100. Salmonella typhimurium strains TA1535, TA1537 and TA1538 are not sensitive to the mutagenic action of cis-PDD. All 5 strains are sensitive to the toxic effect of cis-PDD. Platinum(II) complexes induce mutations (frame-shift or base-pair substitution) only in strains carrying the R-factor plasmid.[Abstract] [Full Text] [Related] [New Search]