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  • Title: [Results and prognostic factors in the treatment of chronic active hepatitis with prednisone and azathioprine].
    Author: Jorge AD, Sánchez D.
    Journal: Acta Gastroenterol Latinoam; 1985; 15(4):233-41. PubMed ID: 3842554.
    Abstract:
    Fifty-two patients with active chronic hepatitis (A.C.H.) were treated with prednisone and azathioprine simultaneously. Seventy-three per cent of the patients were cured. Healing was obtained in 94% of the patients who did not reveal necrotic bridging prior to treatment, while only 43% of the patients who had this sign was cured. Eighty-one per cent of the cases with no A- no B active chronic hepatitis was cured, while only in 66% of patients with B A.C.H. remission was obtained. All the Non A- Non B A.C.H. patients who recovered did so in less than 3 years, while only 40% of the B + A.C.H. patients obtained complete remission in the same period of time. The remaining 60% of the B + A.C.H. group recovered in a period ranging from 3 to 12 years. In the B + A.C.H. group 75% patients of the male sex were cured, while only 33% of the females recovered. Active cirrhosis was seen in 7.6% of cases. All of them were B+. Mortality rate was 3.8 and only the B + group was affected. In conclusion it must be remarked that the presence of necrotic bridging, virus B and female sex were the factors that revealed the worst prognosis as response of A.C.H. to the combined treatment of prednisone and azathioprine.
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