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  • Title: Clinical experience with clobazam: a new 1,5 benzodiazepine in the treatment of refractory epilepsy.
    Author: Vajda FJ, Bladin PF, Parsons BJ.
    Journal: Clin Exp Neurol; 1985; 21():177-82. PubMed ID: 3843217.
    Abstract:
    A benzodiazepine drug, clobazam, was evaluated in 14 refractory epileptic patients, nine of whom received the drug double-blind. Ten patients have been given clobazam long enough to assess results. Four showed marked benefit, four failed to respond and two showed a transient benefit which was maintained by dose changes of both clobazam and clonazepam. Side effects were minimal; doses ranged from 15 to 60 mg per day. Clobazam may have place in the treatment of the Lennox Gastaut syndrome and other types of refractory seizures.
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