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  • Title: Stereodivergent Synthesis of Alkaloid (±)-223A and (±)-6-epi-223A via Rh-Catalyzed Hydroformylation Double Cyclization.
    Author: Huang WW, Cheng JT, Hsiao WT, Chiou WH.
    Journal: J Org Chem; 2024 Apr 05; 89(7):5091-5097. PubMed ID: 38456271.
    Abstract:
    A stereodivergent approach toward total syntheses of Dendrobatid alkaloids 223A and 6-epi-223A is described. The approach features a concise construction of an indolizidine skeleton by Rh-catalyzed domino hydroformylation double cyclization and sequential stereocontrolled transformations such as reductive alkylation or anti-selective α-alkylation of the 5-oxoindolizidine. These stereoselective reactions afford the desired stereochemistry in the targets.
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