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  • Title: Activatable Dual-Optical Molecular Probe for Bioimaging Superoxide Anion in Epilepsy.
    Author: Si M, Lv L, Shi Y, Li Z, Zhai W, Luo X, Zhang L, Qian Y.
    Journal: Anal Chem; 2024 Mar 19; 96(11):4632-4638. PubMed ID: 38457631.
    Abstract:
    Superoxide anion (O2•-) plays a pivotal role in the generation of other reactive oxygen species within the body and is closely linked to epilepsy. Despite this connection, achieving precise imaging of O2•- during epilepsy pathology remains a formidable challenge. Herein, we develop an activatable molecular probe, CL-SA, to track the fluctuation of the level of O2•- in epilepsy through simultaneous fluorescence imaging and chemiluminescence sensing. The developed probe CL-SA demonstrated its efficacy in imaging of O2•- in neuronal cells, showcasing its dual optical imaging capability for O2•- in vitro. Furthermore, CL-SA was successfully used to observe aberrantly expressed O2•- in a mouse model of epilepsy. Overall, CL-SA provides us with a valuable tool for chemical and biomedical studies of O2•-, promoting the investigation of O2•- fluctuations in epilepsy, as well as providing a reliable means to explore the diagnosis and therapy of epilepsy.
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