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  • Title: The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells.
    Author: Öhman J, Sjölin E, Cundari M, Johansson F, Gilbert M, Boele HJ, Svensson P, Rasmussen A.
    Journal: Cerebellum; 2024 Oct; 23(5):1859-1866. PubMed ID: 38467957.
    Abstract:
    Climbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of rewards, leading to bursts of excitatory postsynaptic potentials (EPSPs) in Purkinje cells. The number of EPSPs is a crucial variable when the brain is learning a new motor skill. Yet, we do not know what determines the number of EPSPs. Here, we measured the effect of nucleo-olivary stimulation on periorbital elicited climbing fiber responses through in-vivo intracellular Purkinje cell recordings in decerebrated ferrets. The results show that while nucleo-olivary stimulation decreased the probability of a response occurring at all, it did not reduce the number of EPSPs. The results suggest that nucleo-olivary stimulation does not influence the number of EPSPs in climbing fiber bursts.
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