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  • Title: Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases.
    Author: Groutas WC, Stanga MA, Brubaker MJ, Huang TL, Moi MK, Carroll RT.
    Journal: J Med Chem; 1985 Aug; 28(8):1106-9. PubMed ID: 3848491.
    Abstract:
    Several congeners of elasnin (I) have been synthesized and shown to inhibit human leukocyte elastase (HLE). The C-3 alkyl substituted 2-pyrones 11 and 12 were found to be the most effective inhibitors of the enzyme. These compounds are highly specific in their inhibitory activity.
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