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  • Title: Two New Benzoquinone Derivatives from Vietnamese Knema globularia Stems.
    Author: Truong Nguyen H, Duong TH, Dang MK, Pham MD, Pham NK, Tri Mai D, Son Dang V, Nguyen NH, Sichaem J.
    Journal: Chem Biodivers; 2024 May; 21(5):e202400380. PubMed ID: 38498616.
    Abstract:
    The chemical investigation of the stems of Knema globularia led to the isolation of two new benzoquinones derivatives, embenones A and B (1 and 2), along with three known compounds (3-5). The structures of the isolated compounds were determined using spectroscopic techniques, including HRESIMS, 1D and 2D NMR, in conjunction with comparison to existing literature data. Compounds 1 and 2 represent new carbon skeletons in nature. Furthermore, all isolated compounds were evaluated for their α-glucosidase inhibitory activity, with compounds 1-3 exhibiting superior potency relative to the positive control (acarbose, IC50 331 μM). Their IC50 values ranged from 1.40 to 96.1 μM.
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