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  • Title: A single dose comparison of piretanide and bumetanide in congestive cardiac failure.
    Author: Homeida M, Roberts CJ, Dombey SL.
    Journal: Br J Clin Pharmacol; 1979 Aug; 8(2):173-8. PubMed ID: 385025.
    Abstract:
    1 This study has compared the diuresis produced by a single oral administration of 6 mg piretanide, 9 mg piretanide and 1 mg bumetanide in a group of nine patients with cardiac failure using a balanced randomized design. 2 The natriuresis and kaliuresis produced in the first 6 h after administration of piretanide 9 mg and bumetanide 1 mg were similar. Piretanide 6 mg produced a lesser response. 3 There was evidence of sodium and water conservation following the diuresis for up to 48 h with all three treatments. 4 The patterns of urate and calcium excretion were similar for the two diuretics.
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