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  • Title: The effects of repeated administration of Escherichia coli lipopolysaccharides to ponies.
    Author: Burrows GE.
    Journal: Can J Comp Med; 1979 Jul; 43(3):321-7. PubMed ID: 385123.
    Abstract:
    Repeated exposure of ponies in Escherichia coli endotoxin resulted in attenuation of the packed cell volume, beta-glucuronidase, capillary refill time and neutrophil responses usually accompanying endotoxin administration. An overall decrease in severity of clinical response including reduced mortality was also apparent in ponies with repeated endotoxin exposure. Modification of the febrile response was not observed in any of the experimental groups.
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