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  • Title: A Case Report on Endometrial Receptivity Array Test for Infertile Patient to Enhance Reproductive Outcomes.
    Author: Khan M, More A, Bawaskar PA, Kalbande A, Nair N.
    Journal: Cureus; 2024 Feb; 16(2):e55059. PubMed ID: 38550432.
    Abstract:
    The issue of infertility affects couples all over the world. Recurrent implantation failure (RIF) is caused by immunology, thrombophilias, endometrial receptivity, microbiota, anatomical anomalies, male factors, and embryo aneuploidy. An accurate evaluation of endometrial receptivity (ER) in cases of RIF during in-vitro fertilization (IVF) treatments is crucial to improve reproductive outcomes. To find her accurate window of implantation (WOI), a 34-year-old woman with unexplained RIF underwent an endometrial receptivity array (ERA) test. This case study examines her inexplicable RIF and reproductive results. The ERA test examined gene expression patterns in endometrial tissue to determine the receptive phase for proper embryo transfer. Primary infertility, ineffective intrauterine insemination (IUI), and several unsuccessful IVF rounds were all part of the patient's medical history. Her WOI determined the embryo transfer timing after getting the ERA test results. The patient's clinical pregnancy was successful. This particular case focuses on the potential of the ERA test to improve reproductive outcomes. However, when using this strategy, it is essential to consider difficulties, including invasiveness and related expenses. In this case, the positive results urge future research to apply customized WOI determination using the ERA test to improve the effectiveness of IVF therapies in patients with recurrent implantation failure. More extensive investigations and controlled trials are required to confirm these results and the broader applicability of this strategy. The ERA test is promising, but to provide a holistic approach to infertility care, it should be taken into account together with endometrial changes and elements of embryo-endometrial interaction that impact the success of implantation.
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