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  • Title: Relationship of c-myc expression to differentiation and proliferation of HL-60 cells.
    Author: Filmus J, Buick RN.
    Journal: Cancer Res; 1985 Feb; 45(2):822-5. PubMed ID: 3855381.
    Abstract:
    We have compared changes in c-myc expression in HL-60 promyelocytic leukemia cells induced to differentiate by dimethyl sulfoxide or growth inhibited in an undifferentiated state. Under these conditions, c-myc expression did not correlate with the proportion of proliferating cells. The kinetics of the decrease in c-myc expression upon differentiation induction is paralleled closely by an increasing proportion of histochemically detected differentiated myeloid cells and by a decrease in clonogenic potential but not by changes in the proportion of proliferating cells. Changes in c-myc expression subsequent to differentiation induction can therefore be directly related to the differentiation process rather than to a cell cycle-related phenomenon.
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