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  • Title: High-dose ifosfamide in advanced osteosarcoma.
    Author: Marti C, Kroner T, Remagen W, Berchtold W, Cserhati M, Varini M.
    Journal: Cancer Treat Rep; 1985 Jan; 69(1):115-7. PubMed ID: 3855382.
    Abstract:
    In a prospective study, 18 evaluable patients with recurrent osteosarcoma were treated with ifosfamide, 1.8 g/m2 daily for 5 consecutive days. Courses were repeated every 4 weeks. Additional mesna (2-mercaptoethane sulfonate) was given to prevent urotoxicity. All patients had measurable lung deposits and all but one had been pretreated with various cytotoxic agents. Six patients (33%) showed therapeutic response, two complete and four partial, with a median duration of 5.5 months (range, 3-47+). Toxicity included myelosuppression, alopecia, nausea, and vomiting. No severe urotoxicity or central nervous system toxicity was observed. Thus, high-dose ifosfamide in combination with mesna seems to be a safe and effective agent for the chemotherapy of osteosarcoma.
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