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  • Title: Philadelphia-chromosome-negative chronic myelogenous leukemia with lymphoid stem cell blastic transformation.
    Author: Kessler JF, Grogan TM, Greenberg BR.
    Journal: Am J Hematol; 1985 Feb; 18(2):201-6. PubMed ID: 3855600.
    Abstract:
    A patient is described who had blastic transformation of Ph1 negative chronic myelogenous leukemia (Ph1 - CML). Characterization of the leukemic cells revealed a population with a lymphoid stem cell phenotype (cALL-, TdT+, Ia+, cIgM-). This particular phenotype may be responsible for the refractoriness to vincristine and prednisone and the rapid downhill course.
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