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Title: Unusual Ph translocations in CML: four new cases. Author: Sessarego M, Ajmar F, Bianchi Scarrà GL, Ravazzolo R, Garré C, Boccaccio P. Journal: Cancer Genet Cytogenet; 1985 Feb 15; 15(3-4):199-207. PubMed ID: 3855686. Abstract: Four variants of the Ph chromosome translocation in chronic myelogenous leukemia (CML) patients are described. Two had an unusual simple translocation involving chromosomes #7 and #17. In two cases, the translocation, aside from involving #9 and #22, involved a third chromosome, chromosome #6 and chromosome #11, respectively. Three cases showed also karyotypic evolution during the blastic phase of the disease: in two cases, a new reciprocal translocation was found that involved a chromosome #9 at band q34. The clinical and cytogenetic significance of these results is briefly discussed.[Abstract] [Full Text] [Related] [New Search]