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  • Title: Vindesine-prednisone in the treatment of blast crisis of chronic myeloid leukemia.
    Author: Lemoine F, Najman A, Laporte JP, Gorin NC, Duhamel G.
    Journal: Cancer Treat Rep; 1985 Feb; 69(2):203-4. PubMed ID: 3855698.
    Abstract:
    Eight patients with chronic myeloid leukemia in blast crisis were treated with a combination of vindesine and prednisone. Complete remission was achieved in three patients; partial remission was achieved in three. All six responders received maintenance treatment with hydroxyurea and 6-mercaptopurine. The median duration of survival was 9 months. Two patients had long-term survival: one survived 32 months and the other is alive after 30 months. These data suggest that vindesine-prednisone polychemotherapy might improve the prognosis of blast crisis in chronic myeloid leukemia.
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