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  • Title: Effects of theophylline on small human placental arteries in vitro.
    Author: Nielsen-Kudsk JE.
    Journal: Acta Pharmacol Toxicol (Copenh); 1985 Jan; 56(1):14-9. PubMed ID: 3856378.
    Abstract:
    Effects of theophylline on contractions induced by relevant physiological agents in tubular segments of small human placental arteries were measured in an isometric myograph. Theophylline 10(-7) - 3 X 10(-3)M caused marked relaxation of steady contractions produced by prostaglandin F2 alpha (PGF2 alpha), prostaglandin E2 (PGE2), vasopressin or potassium. EC50 for theophylline relaxation of the PGF2 alpha - contraction was 1.6 X 10(-4) M. Emax was 91.5% relaxation. Theophylline was less potent in relaxing the potassium induced contraction. Pretreatment experiments with 10(-4) and 10(-3)M theophylline showed a pronounced decrease in contractile Emax-values for PGF2 alpha, PGE2 and vasopressin as a possible indication of non-competitive antagonism. The results motivate further studies to elucidate possible effects of theophylline and other xanthines on the vascular resistance and blood flow in placenta.
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