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  • Title: Full expression of blood group-related, transplantation-related, and carcinoembryonic antigens in human colorectal cancer cells with different degrees of phenotypic differentiation.
    Author: Drewinko B, Lichtiger B.
    Journal: Cancer Res; 1985 Apr; 45(4):1560-4. PubMed ID: 3856476.
    Abstract:
    Seven established human colon carcinoma cell lines with distinct degrees of phenotypic differentiation were evaluated for the presence of blood group-related and transplantation-related antigens in relation to their production of carcinoembryonic antigen (CEA). All lines presented A and B antigens regardless of the patients' original red blood cell type. However, tumor cells from patients originally classified as O-type had lower expression of both A and B antigens and high production of CEA. Cells from patients with an original A type had low to undetectable CEA production and high expression of both A and B antigens. There was no particular segregation of transplantation-related antigens with respect to phenotypic expression. All lines presented HLA-A, -B, and -C, as well as -DR antigens. These results demonstrate that colon carcinoma cells have the ability to fully express both blood group-related and transplantation-related antigens, even if discordant with the donor's red blood cell phenotype. Furthermore, it appears that expression of A antigen is intimately related to synthesis of CEA.
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