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  • Title: Human histocompatibility antigen associations in patients with chronic cutaneous lupus erythematosus.
    Author: Fowler JF, Callen JP, Stelzer GT, Cotter PK.
    Journal: J Am Acad Dermatol; 1985 Jan; 12(1 Pt 1):73-7. PubMed ID: 3856581.
    Abstract:
    Increased frequency of certain human leukocyte antigens (HLA) has been reported in various subsets of patients with lupus erythematosus (LE). Specifically, HLA-B8 and HLA-DR3 have been associated with subacute cutaneous LE; HLA-DR3 or HLA-DR2 is found in mothers of infants with neonatal LE; and HLA-A1, HLA-B8, HLA-B15, and HLA-DR2 occur in patients with systemic LE. We typed twenty-two white and nineteen black patients with chronic cutaneous (discoid) LE (DLE) for the A, B, and DR loci of the HLA antigens. HLA-DRw6 was found in an increased proportion of our patients of both races compared with controls. HLA-B8 was found more frequently in white DLE patients than in white control subjects. Thus a genetic predisposition may be a factor that explains the variation in disease expression.
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