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  • Title: Gingival wound healing in the presence of plaque-induced inflammation.
    Author: Yumet JA, Polson AM.
    Journal: J Periodontol; 1985 Feb; 56(2):107-19. PubMed ID: 3856654.
    Abstract:
    An accelerated loss of connective tissue attachment has been reported following surgery in plaque-infected dentitions. It was the purpose of the present study to evaluate histologically the healing of incisional wounds in the gingival supracrestal region in the presence and absence of bacterially induced inflammation. In the experimental group, marginal periodontitis was induced around the teeth by tying plaque-retentive ligatures at the gingival margins and 10 weeks later an incisional wound was made from within the gingival sulcus to the crest of the bone. In the control group, similar incisional wounds were made in normal gingiva. In each group, three specimens were available for histologic and histometric analysis 1, 3, 7 and 21 days after wounding. In the control group, the wound healing sequence in the supracrestal region was similar to that reported following incisional cutaneous wounds. In the experimental group, epithelial continuity across the wound was re-established earlier, and marked invagination of epithelium occurred into the incision. This invagination was significantly greater than in control specimens at all time points. In addition, within the experimental group a second significant epithelial migration into the wound occurred between 7 and 21 days. The epithelial invagination extended through the major portion of the supracrestal area and terminated near the cementum surface. It is conceivable that marked epithelial invagination into a supracrestal wound may predispose to an accelerated loss of connective tissue attachment.
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