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  • Title: Tricyclic antidepressants antagonize prostaglandin (PG) E2-induced contractions of the guinea pig ileum and hypomotility in the mouse.
    Author: Tayo FM.
    Journal: Experientia; 1985 Apr 15; 41(4):474-6. PubMed ID: 3857186.
    Abstract:
    The interactions of PGE2 and 2 tricyclic antidepressants were tested both on the guinea pig ileum and motility in the mouse. PGE2-induced contractions of the guinea pig ileum were irreversibly blocked by amitriptyline and desipramine. Chronic administration of amitriptyline and desipramine blocked PGE2-induced hypomotility in the mouse.
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