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  • Title: Pathophysiology of Non-Esophageal Eosinophilic Gastrointestinal Disorders.
    Author: Dunn JLM, Spencer LA.
    Journal: Immunol Allergy Clin North Am; 2024 May; 44(2):299-309. PubMed ID: 38575225.
    Abstract:
    Eosinophilic gastrointestinal disorder (EGID) is an umbrella term encompassing a group of chronic, immune-mediated disorders characterized by eosinophil-rich inflammation affecting one or more segments of the gastrointestinal tract. A recent consensus in nomenclature and emerging data made possible through multi-center consortia are beginning to unravel the molecular and cellular underpinnings of EGIDs below the esophagus. These emerging findings are revealing both overarching commonalities related to a food allergen-driven, chronic, Th2-mediated immune response as well as location-specific nuances in the pathophysiology of the collective EGIDs. Altogether, these advances offer promise for improved diagnoses and more efficacious interventional strategies.
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