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  • Title: Effects of antidepressant withdrawal on the dexamethasone suppression test.
    Author: Dilsaver SC, Greden JF.
    Journal: Psychiatry Res; 1985 Feb; 14(2):11-22. PubMed ID: 3857651.
    Abstract:
    Withdrawal of antidepressant medications may be a source of variance in dexamethasone suppression test (DST) results. We investigated this issue retrospectively through the serial analysis of postdexamethasone plasma cortisol concentrations and clinical severity in 15 patients and 9 control subjects before, during, and after antidepressant withdrawal. Postdexamethasone cortisol concentrations were significantly higher during the antidepressant withdrawal phase. Drug-withdrawal subjects also had an increased frequency of DST nonsuppression. Recent withdrawal of antidepressants requires further study as a possible source of variance for hypothalamic-pituitary-adrenal measures.
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