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  • Title: Secondary plasma cell leukaemia (PCL) with plasmablastic morphology.
    Author: Xu K, Nacheva E.
    Journal: J Hematop; 2024 Jun; 17(2):117-119. PubMed ID: 38580782.
    Abstract:
    A 71-year-old female with relapsed IgA lambda myeloma developed progressive cytopenia. The peripheral blood film showed 5% blastoid cells. Flow cytometry analysis was indicative of plasma cells. The bone marrow smear was packed with plasmablasts. Target CD138-cell FISH and molecular karyotyping identified a complex genome. NGS identified high-risk mutations. Bone marrow histology confirmed myeloma with no evidence of acute leukaemia. The patient was diagnosed with plasmablastic progression of myeloma and secondary PCL. Secondary PCL patients have a poor prognosis. It is essential to recognize this subtype and explore a novel treatment approach.
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