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  • Title: An unexpected potent positive chronotropic effect of (15S)-15-methyl-prostaglandin E1 in the isolated guinea-pig right atria.
    Author: Uzun O, Akarsu ES, Türker RK.
    Journal: Prostaglandins Leukot Med; 1985 Apr; 18(1):1-7. PubMed ID: 3858887.
    Abstract:
    The effects of (15S)-15-methyl-prostaglandin E1, a synthetic analog of PGE1, other stable prostaglandins, histamine and noradrenaline were studied on the isolated spontaneously beating right atria from guinea-pig, rat and rabbit. When compared with other prostaglandins, histamine and noradrenaline, 15-methyl analog of PGE1 has the most potent positive chronotropic effect and the highest affinity as indicated by a significantly higher pD2 value as compared to other tested analogs in the isolated guinea-pig right atria. Neither the 15-methyl analog of PGE1 nor other stable prostaglandins induced any effect on the atria from rat and rabbit when relatively higher concentrations were used. 15-Methyl-PGE1 did not induce a positive inotropic effect. The maximum positive chronotropic response to 15-methyl-PGE1 was found to be about 60% of that of noradrenaline and histamine but almost equal to that of PGE1. These results were taken as evidence that 15-methyl-PGE1 has an unexpected potent positive chronotropic effect on the isolated spontaneously beating guinea-pig right atrium. The possible mechanism of the action of 15-methyl-PGE1 are discussed.
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