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  • Title: The HLA-A, -B, and -DR phenotypes and tuberculosis.
    Author: Hwang CH, Khan S, Ende N, Mangura BT, Reichman LB, Chou J.
    Journal: Am Rev Respir Dis; 1985 Aug; 132(2):382-5. PubMed ID: 3861112.
    Abstract:
    The HLA-A, -B, and -DR antigens were studied in black Americans to analyze deviation in phenotype distribution between ATS Class 3 patients with tuberculosis disease and ATS Class 2 healthy persons with significant tuberculin reaction, but no tuberculosis. Statistical analyses with Fisher's exact test revealed a significant difference in frequency distribution of HLA-B5 (p = 0.046), HLA-DR5 (p = 0.0276), and HLA-DR6y (p = 0.0095) between ATS Class 2 and ATS Class 3 patients. There was a significant decrease in HLA-DR6y (p = 0.01) but increase in HLA-B5 and HLA-DR5 phenotypes in ATS Class 3 patients.
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