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  • Title: Presence of nucleosomal repeat in the transcribed alpha globin gene of induced murine erythroleukemia cells.
    Author: Kirov N, Tsaneva I, Tsanev R.
    Journal: Biochem Biophys Res Commun; 1985 Jul 16; 130(1):364-71. PubMed ID: 3861179.
    Abstract:
    The sensitivity of the mouse alpha-globin gene to micrococcal nuclease and its nucleosomal repeat were studied in three different functional states of the gene: inactive in EAT cells, potentially active in uninduced MEL cells and active in induced MEL cells. The results show that: 1. The nuclease sensitivity of the gene differs in the three different functional states. 2. Both the coding and the 5'-flanking regions of the induced actively transcribed gene show a typical nucleosomal repeat pattern. 3. Hypersensitive sites for micrococcal nuclease and for an endogenous nuclease appear upstream of the gene after induction of differentiation.
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