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  • Title: Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone.
    Author: Goeddel DV, Heyneker HL, Hozumi T, Arentzen R, Itakura K, Yansura DG, Ross MJ, Miozzari G, Crea R, Seeburg PH.
    Journal: Nature; 1979 Oct 18; 281(5732):544-8. PubMed ID: 386136.
    Abstract:
    DNA coding for human growth hormone was constructed by using chemically synthesised DNA in conjunction with enzymatically prepared cDNA. This 'hybrid' gene was expressed in Escherichia coli under the control of the lac promoter. A polypeptide was produced having the size and immunological properties characteristic of mature human growth hormone.
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