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  • Title: [Intraocular penetration of systemically administered cephalosporins under steady-state conditions in animal experiments].
    Author: Völker B, Mester U, Mendel N.
    Journal: Ophthalmologica; 1985; 191(1):29-34. PubMed ID: 3861992.
    Abstract:
    In previous studies of intraocular penetration of systemically applied antibiotics a single dose of the antibiotic was applied. An experimental study was performed in order to determine if maintaining a constant serum level for an extended period of time will lead to an increase in ocular concentration. The antibiotic dosage was calculated so that the serum level remained constant for a given period of time. Using the rabbit as an experimental animal two cephalosporins (Cefsulodin, Cefotiam) were then injected intravenously using an infusion pump. Evaluation of serum levels (high-performance liquid chromatography) revealed constant levels for each animal but different interindividual levels. The intraocular concentrations of Cefsulodin and Cefotiam were different. The intraocular level of Cefsulodin rose continuously over a period of 5 h, whereas the Cefotiam levels remained at the concentration measured after bolus injection.
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