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  • Title: The activity of imipenem on Legionella pneumophila, with a note on the treatment of two cases.
    Author: Farrell ID, Barker J, Chiodini PL, Hutchison JG, Geddes AM.
    Journal: J Antimicrob Chemother; 1985 Jul; 16(1):61-5. PubMed ID: 3862660.
    Abstract:
    An in-vitro assessment of the activity of imipenem, a new carbapenem beta-lactam antibiotic, was undertaken on isolates of Legionella pneumophila. The minimum inhibitory concentrations of imipenem were in the range 0.03 to 0.25 mg/l and turbidimetric studies showed that imipenem had a marked bactericidal effect which was more pronounced than that seen with either rifampicin or erythromycin. Two patients with legionella pneumonia were successfully treated with imipenem as part of a clinical trial of the drug.
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