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  • Title: Dexamethasone effect on renal prostaglandin-9-ketoreductase activity in the rabbit.
    Author: Naray-Fejes-Toth A, Fejes-Toth G.
    Journal: Prostaglandins Leukot Med; 1985 Aug; 19(2):133-7. PubMed ID: 3863150.
    Abstract:
    The effect of in vivo administration of dexamethasone (1 mg/kg/d for 1 wk) was investigated on the ratio of urinary PGE2/PGF2 alpha excretion and on in vitro cortical prostaglandin-9-ketoreductase (PG-9-KR) activity in rabbits. Dexamethasone treatment decreased PGF2 alpha excretion significantly from 32.87 +/- 8.09 to 19.28 +/- 6.14 ng/mg creatinine, p less than 0.05) without causing a significant change in PGE2 excretion (9.38 +/- 2.48 and 13.53 +/- 5.03 ng/mg creatinine before and after dexamethasone, respectively). The ratio of urinary PGE2/PGF2 alpha increased markedly following glucocorticoid administration (from 0.34 +/- 0.08 to 1.03 +/- 0.32, p less than 0.05). The activity of cytosolic PG-9-KR activity, however, was not significantly different in control and dexamethasone-treated rabbits. It is concluded that the glucocorticoid-induced increase in urinary PGE2/PGF2 alpha ratio is probably unrelated to changes in PG-9-KR activity.
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