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  • Title: Assessment of the pyrogenic potency of the thromboxane A2-mimetics, SQ26655 and U46619, and thromboxane B2 by intrapreoptic injection in the cat.
    Author: Gollman HM, Rudy TA.
    Journal: Res Commun Chem Pathol Pharmacol; 1985 Aug; 49(2):305-8. PubMed ID: 3864207.
    Abstract:
    Using bilateral injection into the anterior hypothalamic/preoptic region of the conscious, indomethacin pretreated cat as an assay system, the pyrogenic activity of two thromboxane A2-mimetics (SQ26655 and U46619) and thromboxane B2 was assessed. PGE2 was used as a reference pyrogenic agent. Thromboxane B2 and both of the thromboxane A2-mimetics were at least 5263 times less potent than PGE2. The results do not support the putative role of thromboxanes as mediators of fever.
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