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  • Title: Benign mixed mammary tumor with sebaceous differentiation in a dog.
    Author: Ma Y, Shi J, Lu H, Zhang J, Liu Z, Wei J, Zhao K, Gao F, He W.
    Journal: J Vet Med Sci; 2024 Jun 19; 86(6):684-688. PubMed ID: 38644184.
    Abstract:
    We describe here a case of canine mammary benign mixed tumor with sebaceous metaplasia in the right fifth mammary gland of an eight-year-old, intact female Poodle dog. Grossly, the mass was firm with off-white, poorly lobulated cut surfaces. Histologically, the luminal epithelial cells and myoepithelial cells proliferated with cartilage formation and focal squamous metaplasia. Moreover, a large number of nests of various sizes, which were filled with foamy cells in the center and associated with basaloid reserve-like cells in the periphery, showed sebaceous gland-like structures. Immunohistochemically, myoepithelial cells and reserve-like cells in the metaplastic sebaceous gland-like structures were CK14, α-smooth muscle actin (α-SMA) and p63 positive, suggesting a possibility that these two components may have a common cell of origin.
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