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  • Title: Analysis on acupoint selection rules in the treatment of metabolism-associated fatty liver disease based on data mining.
    Author: He YJ, He JJ, Fan YS, Miao FR, Zhang H, Lin R, Qin NJ.
    Journal: Zhen Ci Yan Jiu; 2024 Apr 25; 49(4):424-433. PubMed ID: 38649212.
    Abstract:
    OBJECTIVES: To explore the rules of acupoint selection in the treatment of metabolic-associated fatty liver disease (MAFLD) with acupuncture and moxibustion by using data mining technology. METHODS: The clinical research literature on acupuncture treatment of MAFLD was collected from PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, VIP Database and China Biology Medicine from their inception to November 20, 2022. According to our inclusion and exclusion criteria, the literature was independently screened and re-screened by two research members, and the screened results were checked, followed by establishing an acupoint prescription database using Excel 2019. Descriptive statistics of acupoints applied frequency, involved meridians, locations and specific acupoints were perpormed. Then, SPSS Modeler18.0 software was used to conduct analysis about association rules, and the SPSS Statistics 26.0 software was used to perform cluster analysis on high-frequency acupoints, exploring the characteristics and rules of acupoint selection and combination in the treatment of MAFLD. RESULTS: Totally, 178 papers were collected, containing 130 acupoints, with a total application frequency of 1 305. The top five acupoints are Zusanli (ST36), Fenglong (ST40), Ganshu (BL18), Taichong (LR3) and Sanyinjiao (SP6). The commonly involved meridians are the Stomach Meridian of Foot Yangming, Bladder Meridian of Foot Taiyang, and Spleen Meridian of Foot Taiyin. The employed acupoints are mostly located in the lower limbs and abdomen, and the five Shu acupoints and crossing acupoints are in the majority. The association rule analysis of high frequency acupoints indicated that of the 16 qualified acupoint groups, the top 5 with close correlation degrees are ST36 and ST40, ST36 and LR3, ST36 and SP6, ST40 and LR3 and ST36, ST36 and SP6 and ST40. Further, 3 effective clusters were obtained by cluster analysis. CONCLUSIONS: Acupuncture and moxibustion treatment of MAFLD follows the therapeutic principles of soothing the liver, invigorating the spleen, tonifying the kidney, and resolving phlegm and removing dampness. The core acupoint group is ST36, ST40 and LR3, and the combination of acupoints is based on syndrome differentiation. These results may provide a useful reference for clinical practice. 目的: 运用数据挖掘技术，探讨针灸治疗代谢相关脂肪性肝病（MAFLD）的选穴规律。方法: 检索PubMed、Embase、Cochrane Library、中国知网数据库、万方数据库、维普数据库、中国生物医学文献数据库从建库至2022年11月20日收录的有关针灸治疗MAFLD的临床研究类文献，利用Excel 2019建立用穴处方数据库，对腧穴进行频数、归经、部位、特定穴描述性统计，采用SPSS Modeler 18.0、SPSS Statistics 26.0软件分别对高频腧穴进行关联规则和聚类分析，探究针灸治疗MAFLD的选穴特点及规律。结果: 共纳入178篇文献，包含130个腧穴，总频次1 305次。高频腧穴为足三里、丰隆、肝俞、太冲、三阴交等，常用经脉为足阳明胃经、足太阳膀胱经与足太阴脾经，涉及的腧穴多位于下肢部和腹部，以五输穴和交会穴为多。关联度前5的穴位组合为“足三里-丰隆”“足三里-太冲”“足三里-三阴交”“丰隆-太冲-足三里”“足三里-三阴交-丰隆”，并得到16组关联规则和3个有效聚类群。结论: 针灸治疗MAFLD的选穴遵循疏肝、补脾、益肾、化痰、祛湿的治疗原则，核心穴组为“足三里-丰隆-太冲”，并辨证配穴，可为临床提供参考依据。.
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