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  • Title: Nickel-catalyzed γ-alkylation of cyclopropyl ketones with unactivated primary alkyl chlorides: balancing reactivity and selectivity via halide exchange.
    Author: Wang ZY, Liu SZ, Guo C, Cheng YZ, Li Q, Dou J, Li D.
    Journal: RSC Adv; 2024 Apr 16; 14(18):12883-12887. PubMed ID: 38650692.
    Abstract:
    A novel method was developed for synthesizing γ-alkyl ketones via nickel-catalyzed cross-electrophile coupling of cyclopropyl ketones and non-activated primary alkyl chlorides. High reactivity and selectivity can be achieved with sodium iodide as a crucial cocatalyst that generates a low concentration of alkyl iodide via halide exchange, thus avoiding the formation of alkyl dimers. This reaction possessed excellent regioselectivity and high step economy circumventing in situ or pregenerated organometallics.
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