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  • Title: New eremophilane-type sesquiterpenes from Synotis solidaginea.
    Author: Wei XY, Sun HB, Xi RY, Wu F, Liu YL, Jin ZL, Guo DL, Xia B, Wang F, Zhou Y.
    Journal: Fitoterapia; 2024 Jun; 175():105970. PubMed ID: 38653340.
    Abstract:
    Eleven new highly oxygenated eremophilane-type sesquiterpenoids were isolated from the whole plant of Synotis solidaginea, including two pairs of C-8 S/R epimers. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and the absolute configurations of 1 and 9 were confirmed by single-crystal X-ray crystallography using Cu Kα radiation. All the isolates were tested for the inhibition of LPS-stimulated NO production in macrophage-like mouse monocytic leukemia RAW264.7 cells. Compound 1 exhibited weak inhibitory effects with an IC50 of 71.2 μM.
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