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  • Title: Candida albicans cDNA library screening reveals novel potential diagnostic targets for invasive candidiasis.
    Author: Bregón-Villahoz M, Menéndez-Manjón P, Carrano G, Díez-Villalba A, Arrieta-Aguirre I, Fernandez-de-Larrinoa I, Moragues MD.
    Journal: Diagn Microbiol Infect Dis; 2024 Jul; 109(3):116311. PubMed ID: 38657353.
    Abstract:
    The detection of patterns associated with the invasive form of Candida albicans, such as Candida albicans germ tube antibodies (CAGTA), is a useful complement to blood culture for Invasive Candidiasis (IC) diagnosis. As CAGTA are detected by a non-standardisable and non-automatable technique, a Candida albicans cDNA expression library was screened with CAGTA isolated from serum of an animal model of invasive candidiasis, and five protein targets were identified: hyphally regulated cell wall protein 1 (Hyr1), enolase 1 (Eno1), coatomer subunit gamma (Sec21), a metallo-aminopeptidase (Ape2) and cystathionine gamma-lyase (Cys3). Homology with proteins from other organisms rules out Cys3 as a good biomarker while Sec21 results suggest that it is not in the germ tubes surface but secreted to the external environment. Our analysis propose Ape2, Sec21 and a region of Hyr1 different from the one currently being studied for immunoprotection as potential biomarker candidates for the diagnosis of IC.
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