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  • Title: Premature Pubarche: A Pragmatic Approach.
    Author: Kaplowitz PB.
    Journal: Endocrinol Metab Clin North Am; 2024 Jun; 53(2):203-209. PubMed ID: 38677863.
    Abstract:
    Premature pubarche (PP) is a common and usually benign variant of normal puberty most often seen in 5-year-old to 9-year-old children. Some providers routinely order laboratory testing and a bone age to try to rule out other diagnoses including nonclassic congenital adrenal hyperplasia and gonadal or adrenal tumors. I review the natural history of PP and studies which suggest that without clinical features such as rapid growth and progression or genital enlargement, it is unlikely that a treatable condition will be found. Therefore it is recommended that patients with PP not undergo testing unless there are red flags at the time of the initial visit.
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