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  • Title: Intestinal pathology in the dog induced by sublethal doses of amiodarone.
    Author: Vic P, Gouy D, Lacheretz F, Verschuere B, Cros M, Remandet B, Berthe J, Mazue G.
    Journal: Arch Toxicol Suppl; 1985; 8():104-9. PubMed ID: 3868338.
    Abstract:
    Amiodarone (A), an unique antiarrhythmic agent and amphiphilic drug, induces at sublethal doses dyslipidic storage in animals. The present work demonstrates a distinct intestinal pathology or "Malabsorption Syndrome" in the dog induced by A. Signs of intestinal pathology were observed in all animals receiving 100 mg/kg, but not in those receiving less than 50 mg/kg, after one month. The malabsorption syndrome was demonstrated by a dynamic study of lipid absorption and pathological lesions (partial villous atrophy and the accumulation of macrophages with dyslipidic inclusions.
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