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  • Title: High serum levels of alkaline phosphatase are associated with cancer in cholestatic jaundice.
    Author: Wilson JW, Kronborg IJ, Roberts-Thomson IC.
    Journal: Aust N Z J Surg; 1985 Oct; 55(5):453-4. PubMed ID: 3868408.
    Abstract:
    In a prospective study of liver function tests in cholestatic jaundice, the median serum level of alkaline phosphatase (ALP) in 129 patients with cancer involving extrahepatic ducts and liver (556 IU/1) was significantly higher (P less than 0.001) than that in 121 patients without cancer (264 IU/1). Of patients with an ALP level of greater than 10 X N, 88% had cancer whereas serum levels of ALP of less than 3 X N were observed in only 9% of patients with cancer but in 45% of those without cancer, most of whom had bile duct stones. A high serum level of ALP is associated with cancer involving extrahepatic ducts and liver.
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