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  • Title: Congenital Juvenile Xanthogranuloma in the Perioral Region: A Case Image.
    Author: Maldonado A, Muñoz R, Alarcon N, Ventura JVL, de Andrade BAB, Villarroel-Dorrego M, de Arruda JAA.
    Journal: Head Neck Pathol; 2024 Apr 30; 18(1):35. PubMed ID: 38687428.
    Abstract:
    Juvenile xanthogranuloma (JXG) is the most common form of non-Langerhans cell histiocytosis in childhood. It often presents with cutaneous involvement and exhibits a predilection for the head and neck region. This article illustrates a case of congenital JXG in a 5-month-old boy, characterized by a solitary, well-circumscribed nodule above the left upper lip. Histopathologically, the lesion exhibited histiocytes with eosinophilic cytoplasm and Touton giant cells. Immunohistochemistry revealed histiocytes positive for CD68 and Factor XIIIa, while negative for S-100 protein. Clinicians should become familiar with the broad clinical spectrum of cutaneous JXG, particularly its congenital presentation, in order to ensure timely and accurate management.
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