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  • Title: Cardiovascular effects of intravenously given ATP-MgCl2 in canine hemorrhagic shock.
    Author: Horton JW, Landreneau RJ, Coln CD.
    Journal: Surg Gynecol Obstet; 1985 Mar; 160(3):195-203. PubMed ID: 3871974.
    Abstract:
    Mean arterial blood pressure, cardiac output, stroke volume and rate of left ventricular pressure rise were significantly higher in dogs given lactated Ringer's solution alone compared with dogs given lactated Ringer's solution plus intravenous ATP-MgCl2 complex. The reduced cardiac performance after intravenous ATP-MgCl2 occurred despite adequate coronary blood flow and adequate myocardial oxygen delivery. A decreased myocardial oxygen extraction and a negative myocardial lactate balance after intravenous ATP-MgCl2 indicate a cellular metabolic defect.
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