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  • Title: Pregnancy-associated atypical hemolytic uremic syndrome. Case report.
    Author: Barrera-Hoffmann C, Mariaca-Ortíz Y, Ruiz-Villa JG, Cuevas-Cruz LE, López-Mendoza MDR, Briones-Garduño JC.
    Journal: J Obstet Gynaecol Res; 2024 Jul; 50(7):1268-1272. PubMed ID: 38720638.
    Abstract:
    Pregnancy-associated atypical hemolytic uremic syndrome (P-aHUS) is a rare disease. There are only few reports in the literature, and most are in the puerperium period. It is a thrombotic microangiopathy (TMA) characterized for microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction. We report the case of a pregnant patient at 26.3 gestation weeks, who developed clinical features of TMA, neurological alterations, and septic shock; then after fetus and placental delivery, no clinical improvement was observed; a diagnostic protocol was performed due to suspicion of P-aHUS, showing improvement after the plasma exchange sessions and eculizumab. We present here a brief review of the case since it is an entity that needs to be suspected during pregnancy when TMA features and requires an immediate diagnosis to provide timely treatment.
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