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  • Title: Peanut agglutinin, a marker for T-cell acute lymphoblastic leukemia with a good prognosis.
    Author: Veerman AJ, Hogeman PH, Huismans DR, Van Zantwijk CH, Bezemer PD.
    Journal: Cancer Res; 1985 Apr; 45(4):1890-3. PubMed ID: 3872169.
    Abstract:
    Peanut agglutinin (PNA) binding was studied in cells from 74 children with acute lymphoblastic leukemia (ALL). PNA positivity occurred in 50% of T-ALL (12 of 24) and was rare in other types of ALL. There was no clear relationship between PNA and initial white blood cell count, French-American-British classification, stage of differentiation of leukemic cells, hand mirror cells, and organomegaly at diagnosis. Prognosis, however, was significantly better (continuous complete remission, death) in the PNA-positive T-ALLs. It seems that PNA is a useful marker for a subgroup of T-ALL with a better prognosis.
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