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  • Title: Beta-lactamases from Bacteroides fragilis active against oximino-cephalosporins.
    Author: Werner RG, Appel KR, Erne AM.
    Journal: Arzneimittelforschung; 1985; 35(1A):348-50. PubMed ID: 3872669.
    Abstract:
    Four clinical isolates of Bacteroides fragilis were resistant to penicillins and cephalosporins with exception to 7-alpha-methoxy cephalosporins such as latamoxef (moxalactam) and cefoxitin. In contrast the 6-alpha-methoxy penicillin temocillin was not active. The beta-lactam resistance correlates with the presence of two beta-lactamases with an isoelectric point (IEP) = 4.9 and 5.4, respectively. The necessity of antimicrobial susceptibility testing before the therapy of infections with anaerobic bacteria is discussed.
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