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  • Title: [Changes in the lactate dehydrogenase isoenzyme spectrum during T-lymphocyte differentiation].
    Author: Toporkova LB, Trufakin VA.
    Journal: Tsitologiia; 1985 Feb; 27(2):213-5. PubMed ID: 3873126.
    Abstract:
    The pattern of lactate dehydrogenase isoenzyme spectrum changes on different stages of T-lymphocyte differentiation was studied An enriched population of stem cells has LDH-5, 4 and 3 isoenzymes, and much less LDH-2 activity. The isoenzyme pattern of thymic cell precursors consists of LDH-5, 4, 3 and 2. All the five LDH isoenzymes were found in cortical thymocytes. Medullary thymocytes reveal LDH-5, 4 and 3 isoenzymes. T-lymphocytes of peripheral lymphoid organs contain mainly LDH-5 and in a lesser degree LDH-4 activity.
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