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  • Title: HLA-A, B, C, DR, MT, and MB antigens in recurrent aphthous stomatitis.
    Author: Gallina G, Cumbo V, Messina P, Caruso C.
    Journal: Oral Surg Oral Med Oral Pathol; 1985 Apr; 59(4):364-70. PubMed ID: 3873635.
    Abstract:
    In this report we have investigated the frequencies of HLA-A, B, C, DR, MT, and MB markers in 26 Sicilian subjects affected by recurrent aphthous stomatitis (RAS) and in 84 healthy controls. Our data show that the frequency of HLA-DR7 antigen is significantly increased in RAS-affected persons (61.5% versus 21.4%; pc less than 0.0025), whereas the B5 antigen frequency is decreased significantly (absent in patients versus 27.3% in controls; pc = 0.04). Thus, present results suggest that HLA-linked genetic factors may play a role in the development of RAS.
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