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  • Title: A comparison of Hexabrix and Renografin-60 in knee arthrography.
    Author: Apple JS, Martinez S, Khoury MB, Royster R, Allen S.
    Journal: AJR Am J Roentgenol; 1985 Jul; 145(1):139-42. PubMed ID: 3873834.
    Abstract:
    Forty patients were randomized in a double-blind study to compare the safety and diagnostic quality of Hexabrix vs. Renografin-60 without epinephrine in knee arthrography. Hexabrix is a monoacidic dimer of meglumine and sodium salts of ioxaglic acid with a lower osmolality than conventional contrast agents of similar concentration (32% iodine). Initial films were of equally high diagnostic quality for both groups, but delayed films at 20 and 30 min significantly favored Hexabrix for diagnostic quality. Hexabrix proved to be a safe and effective contrast agent for knee arthrography.
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